Scott, who will be based in London and New York, will be responsible for the delivery of new products across settlement, processing and data.
He will report to Alan Marquard, chief strategy and development officer.
With more than 20 years experience in financial services, Scott was previously head of product strategy and innovation at Euroclear.
Danino-Lewis joins the firm from Broadway Technology, where she was responsible for sales across Broadway’s FX, fixed income and regulatory solutions across EMEA.
Marquard said: “I am very pleased to welcome Angus Scott and Lisa Danino-Lewis to our team and look forward to working with them. Their experience working within leading FX clients means they both have a deep understanding of the challenges facing market participants.”
He added: “This is an exciting time for CLS. We have a significant number of innovative, forward-looking solutions in development that will deliver greater efficiencies, further reduce risk and help our clients to stay at the forefront of a changing market.”